synthesis and the combination effects of dihydropyridine analogs with selected antibiotics against resistant staphylococcus aureus
نویسندگان
چکیده
bacterial resistance is a major drawback in chemotherapy of infectious diseases. in this investigation a new series of 3,5-diarylamide dihydropyridines containing 2-benzylsulfonylimidazol at 4 position have been synthesized and studied for their enhancing effect on the antibacterial activities of different penicillins against a resistant clinical isolate of s. aureus using disc diffusion method. during preliminary screening, compound 6d showed the most enhancing effect on the antibacterial activity of amoxicillin against the test strain and the combination effect of this compound has been further studied with penicillin g and piperacillin against staphylococcus aureus . the result of this evaluation showed that the antibacterial activities of penicillin g and piperacillin can be also enhanced by compound 6d suggesting a possible utilization of this compound in combination therapy against penicillin resistant s. aureus .
منابع مشابه
Effects of Luteolin and Quercetin in Combination with Some Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus
The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics...
متن کاملCombination of Alpha-Melanocyte Stimulating Hormone with Conventional Antibiotics against Methicillin Resistant Staphylococcus aureus
Our previous studies revealed that alpha-melanocyte stimulating hormone (α-MSH) is strongly active against Staphylococcus aureus (S. aureus) including methicillin resistant S. aureus (MRSA). Killing due to α-MSH occurred by perturbation of the bacterial membrane. In the present study, we investigated the in vitro synergistic potential of α-MSH with five selected conventional antibiotics viz., o...
متن کاملSynergistic effect of Thymbra spicata L. extracts with antibiotics against multidrug- resistant Staphylococcus aureus and Klebsiella pneumoniae strains
Objective(s): To evaluate the in vitro interaction between different extracts of Thymbra spicata L. and certain antimicrobial drugs of different mechanisms, including ampicillin, cefotaxime, amikacin and ciprofloxacin. This study was performed against multidrug-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae. Materials and Methods: Evaluation of antibacterial activity and ...
متن کاملDouble Combination of Some Antibiotics Against Local Isolate of Methicillin Resistant Staphylococcus aureus (MRSA)*
We compared in this study the in vitro potency of some antibiotics when used singly and in combination against the multi-drugs resistant Staphylococcus aureus using the wells diffusion in agar. Rifampin, vancomycin, tetracycline and trimethoprim-sulfamethoxazole were randomly selected for this study. The isolate of S. aureus used in this study was previously characterized in our laboratory as m...
متن کاملHydroxyl capped silver-gold alloy nanoparticles: characterization and their combination effect with different antibiotics against Staphylococcus aureus
Objective(s): Metal nanoparticles (NPs) offer a wide variety of potential applications in pharmaceutical sciences due to the unique advances in nanotechnology research. In this work, bimetal Ag-Au alloy NPs were prepared and their combinations with other antibiotics were tested against Staphylococcus aureus. Materials and Methods: Firstly, Ag-Au alloy NPs with Au/Ag molar ratio of 1:1 was f...
متن کاملSynergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus.
Methicillin-resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۳، شماره ۲، صفحات ۲۳-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023